DR CARLO CROCE Office Address 385L Wiseman Hall 410 W TWELFTH AVE COLUMBUS, OH 43210 Phone: 614-292-3063 Email: carlo.croce@osumc.edu Education & Training 1969 Doctor of Medicine University of Rome La Sapienza Positions & Appointments The Wistar Institute of Anatomy and Biology 1970- 1971 Associate Scientist, Philadelphia, PA 1971- 1974 Research Associate , Philadelphia, PA 1974- 1976 Associate Member , Philadelphia, PA 1976- 1980 Professor , Philadelphia, PA The Carnegie Institution 1978- 1978 Sabbatical year in Don Brown's laboratory, Baltimore, MD The National Institutes of Health 1979- 1983 Mammalian Genetics Study Section, Bethesda, MD University of Pennsylvania 1980- 1988 Wistar Professor, Human Genetics, School of Medicine The Wistar Institute of Anatomy and Biology 1980- 1988 Associate Director, Philadelphia, PA 1980- 1991 Institute Professor , Philadelphia, PA Children?s Hospital of Philadelphia 1987- 1991 Wistar Professor, Pediatric Medicine, Philadelphia, PA Temple University 1988- 1991 Director, Fels Institute for Cancer Research and Molecular Biology, School of Medicine 1988- 1991 Professor, Department of Pathology, School of Medicine 1988- 1991 Professor, Department of Medicine, School of Medicine 1989- 1991 Chairman, Graduate Program in Molecular Biology and Genetics, School of Medicine Thomas Jefferson University 1991- 2004 Director, Kimmel Cancer Institute/Kimmel Cancer Center , Medical College The Ohio State University 2004-   The John W. Wolfe Chair, Human Cancer Genetics 2004-   Director, Institute of Genetics 2004-   Director, Human Cancer Genetics Program Professor, Internal Medicine Chair, Molecular Virology, Immunology & Medical Genetics Honors & Awards 1975 Research Career Development Award, The National Institutes of Health, Bethesda MD 1985 Outstanding Investigator Award, The National Institutes of Health, National Cancer Institute, Bethesda MD 1987 Scientific Award, American Cancer Society, Philadelphia Division 1990 Richard and Hinda Rosenthal Foundation Award, Association for Cancer Research 1992 Eagles Fly for Leukemia Lifetime Achievement Award 1992 Scanno Prize for Medicine 1992 Outstanding Investigator Award, The National Institutes of Health, National Cancer Institute, Bethesda MD 1993 Charles S. Mott Prize, General Motors Cancer Research Foundation 1993 John Scott Award 1994 Robert J. and Claire Pasarow Foundation Cancer Award 1994 Honorary Member, Japanese Cancer Association 1995 CLAS Distinguished Scientist Award 1996 National Academy of Sciences MVIMG 1997 Rudolf Virchow Honorary Lectureship, University of Wurzburg, Germany 1997 Scientific Excellence in Medicine Award, American-Italian Cancer Foundation 1997 The Twenty-Fifth Solomon A. Berson Memorial Lecture, Mt. Sinai School of Medicine, NY 1999 Raymond Bourgine Award and Gold Medal of Paris 1999 The 1999 AACR-Pezcoller International Award for Cancer Research, American Association for Cancer Research 1999 The 1999 Herz Memorial Lecture in Cancer Research, Tel Aviv University 2000 Doctor in Medicine, Honoris Causa, Uppsala University, Sweden 2000 Honor of Merit of Italian Republic 2001 Clavius Award for Achievement in Science and Research 2002 Rod and Ceil Mortel Lecture in Cancer Research, Penn State University 2003 Italian Gold Medal for Public Health, Presented by President Ciampi 2003 President of the Republic Prize, Accademia di Lincei 2003 Golgi Lecture, Accademia Nazionale dei Lincei 2003 Foreign Member, Accademia Nazionale delle Scienze, delta dei XL 2004 Premio Beccaria, A. Serra Foundation for Cancer Research 2005 Gottlieb Award, MD Anderson Cancer Center 2006 G.H.A. Clowes Memorial Award, American Association for Cancer Research Courses Research in Entomology (ENTOMOL 999) The Ohio State University, 2005 Research for thesis and dissertation purposes only. Individual Studies (MCD BIO 693) The Ohio State University, 2005 Individual research and problem solving in the field of molecular, cellular, and developmental biology. Research in Molecular, Cellular, and Developmental Biology (MCD BIO 999) The Ohio State University, 2005 Research for thesis and dissertation purposes only. Scholarly Activity Prasad, R; Yano, T; Sorio, C; Nakamura, T; Rallapalli, R; Gu, Y; Leshkowitz, D; Croce, C, M; Canaani, E. "Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia." Proceedings of the National Academy of Sciences of the United States of America. 92. 26 (1995) 12160-4. Rasio, D; Negrini, M; Croce, C M. "Genomic organization of the ATM locus involved in ataxia-telangiectasia." Cancer research. 55. 24 (1995) 6053-7. Fernandes-Alnemri, T; Takahashi, A; Armstrong, R; Krebs, J; Fritz, L; Tomaselli, K, J; Wang, L; Yu, Z; Croce, C, M; Salveson, G. "Mch3, a novel human apoptotic cysteine protease highly related to CPP32." Cancer research. 55. 24 (1995) 6045-52. Schichman, S, A; Croce, C M. "Approaches to the identification and molecular cloning of chromosome breakpoints." Methods in enzymology. 254. (1995) 321-34. Sorio, C; Mendrola, J; Lou, Z; LaForgia, S; Croce, C, M; Huebner, K. "Characterization of the receptor protein tyrosine phosphatase gene product PTP gamma: binding and activation by triphosphorylated nucleosides." Cancer research. 55. 21 (1995) 4855-64. Rasio, D; Negrini, M; Manenti, G; Dragani, T, A; Croce, C M. "Loss of heterozygosity at chromosome 11q in lung adenocarcinoma: identification of three independent regions." Cancer research. 55. 18 (1995) 3988-91. Narducci, M, G; Virgilio, L; Isobe, M; Stoppacciaro, A; Elli, R; Fiorilli, M; Carbonari, M; Antonelli, A; Chessa, L; Croce, C, M; Russo, G. "TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia." Blood. 86. 6 (1995) 2358-64. Negrini, M; Cuneo, A; Nakamura, T; Baffa, R; Sabbioni, S; Alder, H; Castoldi, G; Croce, C M. "A novel t(9;11)(p22;q23) with ALL-1 gene rearrangement associated with progression of a myeloproliferative disorder to acute myeloid leukemia." Cancer genetics and cytogenetics. 83. 1 (1995) 65-70. Negrini, M; Sabbioni, S; Ohta, M; Veronese, M, L; Rattan, S; Junien, C; Croce, C M. "Seven megabase yeast artificial chromosome contig at region 11p15: identification of a yeast artificial chromosome spanning the breakpoint of a chromosomal translocation found in a case of Beckwith-Wiedemann syndrome." Cancer research. 55. 13 (1995) 2904-9. Canaani, E; Nowell, P, C; Croce, C M. "Molecular genetics of 11q23 chromosome translocations." Advances in cancer research. 66. (1995) 213-34. Magdalinski, A; Drwinga, H; Crilley, P; Lasota, J; Brodsky, I; Croce, C, M; Nowell, P, C; Marks, D I. "Translocation 11;14 in newly diagnosed chronic myelogenous leukemia." Cancer genetics and cytogenetics. 81. 1 (1995) 24-7. Baffa, R; Negrini, M; Schichman, S, A; Huebner, K; Croce, C M. "Involvement of the ALL-1 gene in a solid tumor." Proceedings of the National Academy of Sciences of the United States of America. 92. 11 (1995) 4922-6. Haldar, S; Jena, N; Croce, C M. "Inactivation of Bcl-2 by phosphorylation." Proceedings of the National Academy of Sciences of the United States of America. 92. 10 (1995) 4507-11. Veronese, M, L; Ohta, M; Finan, J; Nowell, P, C; Croce, C M. "Detection of myc translocations in lymphoma cells by fluorescence in situ hybridization with yeast artificial chromosomes." Blood. 85. 8 (1995) 2132-8. Nagai, H; Negrini, M; Carter, S, L; Gillum, D, R; Rosenberg, A, L; Schwartz, G, F; Croce, C M. "Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer." Cancer research. 55. 8 (1995) 1752-7. Cimino, G; Rapanotti, M, C; Elia, L; Biondi, A; Fizzotti, M; Testi, A, M; Tosti, S; Croce, C, M; Canaani, E; Mandelli, F. "ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age." Cancer research. 55. 8 (1995) 1625-8. Yu, H; Diamandis, E, P; Levesque, M; Asa, S, L; Monne, M; Croce, C M. "Expression of the prostate-specific antigen gene by a primary ovarian carcinoma." Cancer research. 55. 8 (1995) 1603-6. Yu, H; Diamandis, E, P; Monne, M; Croce, C M. "Oral contraceptive-induced expression of prostate-specific antigen in the female breast." The Journal of biological chemistry. 270. 12 (1995) 6615-8. Bullrich, F; MacLachlan, T, K; Sang, N; Druck, T; Veronese, M, L; Allen, S, L; Chiorazzi, N; Koff, A; Heubner, K; Croce, C M. "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer." Cancer research. 55. 6 (1995) 1199-205. Schichman, S, A; Canaani, E; Croce, C M. "Self-fusion of the ALL1 gene. A new genetic mechanism for acute leukemia." JAMA : the journal of the American Medical Association. 273. 7 (1995) 571-6. Leshkowitz, D; Rozenblatt, O; Nakamura, T; Yano, T; Dautry, F; Croce, C, M; Canaani, E. "ALL-1 interacts with unr, a protein containing multiple cold shock domains." Oncogene. 13. 9 (1996) 2027-31. Veronese, M, L; Schichman, S, A; Croce, C M. "Molecular diagnosis of lymphoma." Current opinion in oncology. 8. 5 (1996) 346-52. Condorelli, G, L; Facchiano, F; Valtieri, M; Proietti, E; Vitelli, L; Lulli, V; Huebner, K; Peschle, C; Croce, C M. "T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice." Cancer research. 56. 22 (1996) 5113-9. Yu, H; Diamandis, E, P; Levesque, M; Giai, M; Roagna, R; Ponzone, R; Sismondi, P; Monne, M; Croce, C M. "Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue." Breast cancer research and treatment. 40. 2 (1996) 171-8. Bullrich, F; Veronese, M, L; Kitada, S; Jurlander, J; Caligiuri, M, A; Reed, J, C; Croce, C M. "Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia." Blood. 88. 8 (1996) 3109-15. Bullrich, F; Fernandes-Alnemri, T; Litwack, G; Alnemri, E, S; Croce, C M. "Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3." Genomics. 36. 2 (1996) 362-5. Vorechovsky, I; Luo, L; Lindblom, A; Negrini, M; Webster, A, D; Croce, C, M; Hammarstrom, L. "ATM mutations in cancer families." Cancer research. 56. 18 (1996) 4130-3. Barnes, L, D; Garrison, P, N; Siprashvili, Z; Guranowski, A; Robinson, A, K; Ingram, S, W; Croce, C, M; Ohta, M; Huebner, K. "Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase." Biochemistry. 35. 36 (1996) 11529-35. Virgilio, L; Shuster, M; Gollin, S, M; Veronese, M, L; Ohta, M; Huebner, K; Croce, C M. "FHIT gene alterations in head and neck squamous cell carcinomas." Proceedings of the National Academy of Sciences of the United States of America. 93. 18 (1996) 9770-5. Bigoni, R; Negrini, M; Veronese, M, L; Cuneo, A; Castoldi, G, L; Croce, C M. "Characterization of t(11;14) translocation in mantle cell lymphoma by fluorescent in situ hybridization." Oncogene. 13. 4 (1996) 797-802. Negrini, M; Monaco, C; Vorechovsky, I; Ohta, M; Druck, T; Baffa, R; Huebner, K; Croce, C M. "The FHIT gene at 3p14.2 is abnormal in breast carcinomas." Cancer research. 56. 14 (1996) 3173-9. Singh, A, D; Croce, C, M; Wary, K, K; Shields, J, A; Donoso, L, A; Shields, C, L; Huebner, K; Ohta, M. "Familial uveal melanoma: absence of germline mutations involving the cyclin-dependent kinase-4 inhibitor gene (p16)." Ophthalmic genetics. 17. 1 (1996) 39-40. Kastury, K; Baffa, R; Druck, T; Ohta, M; Cotticelli, M, G; Inoue, H; Negrini, M; Rugge, M; Huang, D; Croce, C, M; Palazzo, J; Huebner, K. "Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines." Cancer research. 56. 5 (1996) 978-83. Veronese, M, L; Bullrich, F; Negrini, M; Croce, C M. "The t(6;16)(p21;q22) chromosome translocation in the LNCaP prostate carcinoma cell line results in a tpc/hpr fusion gene." Cancer research. 56. 4 (1996) 728-32. Sozzi, G; Alder, H; Tornielli, S; Corletto, V; Baffa, R; Veronese, M, L; Negrini, M; Pilotti, S; Pierotti, M, A; Huebner, K; Croce, C M. "Aberrant FHIT transcripts in Merkel cell carcinoma." Cancer research. 56. 11 (1996) 2472-4. Ohta, M; Berd, D; Shimizu, M; Nagai, H; Nagai, H; Mastrangelo, M; Shields, J, A; Shields, C, L; Croce, C, M; Huebner, K. "Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma." International journal of cancer. Journal international du cancer. 65. 6 (1996) 762-7. Caligiuri, M, A; Strout, M, P; Schichman, S, A; Mrozek, K; Arthur, D, C; Herzig, G, P; Baer, M, R; Schiffer, C, A; Heinonen, K; Knuutila, S; Nousiainen, T; Ruutu, T; Block, A, W; Schulman, P; Pedersen-Bjergaard, J; Croce, C, M; Bloomfield, C D. "Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11." Cancer research. 56. 6 (1996) 1418-25. Haldar, S; Chintapalli, J; Croce, C M. "Taxol induces bcl-2 phosphorylation and death of prostate cancer cells." Cancer research. 56. 6 (1996) 1253-5. Fidanza, V; Melotti, P; Yano, T; Nakamura, T; Bradley, A; Canaani, E; Calabretta, B; Croce, C M. "Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro." Cancer research. 56. 6 (1996) 1179-83. Rasio, D; Schichman, S, A; Negrini, M; Canaani, E; Croce, C M. "Complete exon structure of the ALL1 gene." Cancer research. 56. 8 (1996) 1766-9. Sozzi, G; Veronese, M, L; Negrini, M; Baffa, R; Cotticelli, M, G; Inoue, H; Tornielli, S; Pilotti, S; De Gregorio, L; Pastorino, U; Pierotti, M, A; Ohta, M; Huebner, K; Croce, C M. "The FHIT gene 3p14.2 is abnormal in lung cancer." Cell. 85. 1 (1996) 17-26. Ohta, M; Inoue, H; Cotticelli, M, G; Kastury, K; Baffa, R; Palazzo, J; Siprashvili, Z; Mori, M; McCue, P; Druck, T; Croce, C, M; Huebner, K. "The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers." Cell. 84. 4 (1996) 587-97. Baffa, R; Negrini, M; Mandes, B; Rugge, M; Ranzani, G, N; Hirohashi, S; Croce, C M. "Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach." Cancer research. 56. 2 (1996) 268-72. Brenner, C; Pace, H, C; Garrison, P, N; Robinson, A, K; Rosler, A; Liu, X, H; Blackburn, G, M; Croce, C, M; Huebner, K; Barnes, L D. "Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein." Protein engineering. 10. 12 (1997) 1461-3. Vitale, M; Zauli, G; Bassini, A; Visani, G; Rezzani, R; Croce, C, M; Manzoli, F A. "Selective enrichment in human megakaryocyte progenitors by the B203.13 surface differentiation antigen." British journal of haematology. 99. 4 (1997) 766-9. Monaco, C; Negrini, M; Sozzi, G; Veronese, M, L; Vorechovsky, I; Godwin, A, K; Croce, C M. "Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23." Genomics. 46. 2 (1997) 217-22. Inoue, H; Ishii, H; Alder, H; Snyder, E; Druck, T; Huebner, K; Croce, C M. "Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion." Proceedings of the National Academy of Sciences of the United States of America. 94. 26 (1997) 14584-9. Narducci, M, G; Stoppacciaro, A; Imada, K; Uchiyama, T; Virgilio, L; Lazzeri, C; Croce, C, M; Russo, G. "TCL1 is overexpressed in patients affected by adult T-cell leukemias." Cancer research. 57. 24 (1997) 5452-6. Siprashvili, Z; Sozzi, G; Barnes, L, D; McCue, P; Robinson, A, K; Eryomin, V; Sard, L; Tagliabue, E; Greco, A; Fusetti, L; Schwartz, G; Pierotti, M, A; Croce, C, M; Huebner, K. "Replacement of Fhit in cancer cells suppresses tumorigenicity." Proceedings of the National Academy of Sciences of the United States of America. 94. 25 (1997) 13771-6. Sozzi, G; Tornielli, S; Tagliabue, E; Sard, L; Pezzella, F; Pastorino, U; Minoletti, F; Pilotti, S; Ratcliffe, C; Veronese, M, L; Goldstraw, P; Huebner, K; Croce, C, M; Pierotti, M A. "Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities." Cancer research. 57. 23 (1997) 5207-12. Bigoni, R; Cuneo, A; Roberti, M, G; Bardi, A; Rigolin, G, M; Piva, N; Scapoli, G; Spanedda, R; Negrini, M; Bullrich, F; Veronese, M, L; Croce, C, M; Castoldi, G. "Chromosome aberrations in atypical chronic lymphocytic leukemia: a cytogenetic and interphase cytogenetic study." Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 11. 11 (1997) 1933-40. Sabbioni, S; Barbanti-Brodano, G; Croce, C, M; Negrini, M. "GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development." Cancer research. 57. 20 (1997) 4493-7. Banki, K; Eddy, R, L; Shows, T, B; Halladay, D, L; Bullrich, F; Croce, C, M; Jurecic, V; Baldini, A; Perl, A. "The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5." Genomics. 45. 1 (1997) 233-8. Narducci, M, G; Virgilio, L; Engiles, J, B; Buchberg, A, M; Billips, L; Facchiano, A; Croce, C, M; Russo, G; Rothstein, J L. "The murine Tcl1 oncogene: embryonic and lymphoid cell expression." Oncogene. 15. 8 (1997) 919-26. Prasad, R; Zhadanov, A, B; Sedkov, Y; Bullrich, F; Druck, T; Rallapalli, R; Yano, T; Alder, H; Croce, C, M; Huebner, K; Mazo, A; Canaani, E. "Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax." Oncogene. 15. 5 (1997) 549-60. Cimino, G; Rapanotti, M, C; Biondi, A; Elia, L; Lo Coco, F; Price, C; Rossi, V; Rivolta, A; Canaani, E; Croce, C, M; Mandelli, F; Greaves, M. "Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias." Cancer research. 57. 14 (1997) 2879-83. Srinivasula, S, M; Ahmad, M; Ottilie, S; Bullrich, F; Banks, S; Wang, Y; Fernandes-Alnemri, T; Croce, C, M; Litwack, G; Tomaselli, K, J; Armstrong, R, C; Alnemri, E S. "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis." The Journal of biological chemistry. 272. 30 (1997) 18542-5. Sorio, C; Melotti, P; D'Arcangelo, D; Mendrola, J; Calabretta, B; Croce, C, M; Huebner, K. "Receptor protein tyrosine phosphatase gamma, Ptp gamma, regulates hematopoietic differentiation." Blood. 90. 1 (1997) 49-57. Huebner, K; Hadaczek, P; Siprashvili, Z; Druck, T; Croce, C M. "The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B." Biochimica et biophysica acta. 1332. 3 (1997) M65-70. Rasio, D; Murakumo, Y; Robbins, D; Roth, T; Silver, A; Negrini, M; Schmidt, C; Burczak, J; Fishel, R; Croce, C M. "Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors." Cancer research. 57. 12 (1997) 2378-83. Sozzi, G; Sard, L; De Gregorio, L; Marchetti, A; Musso, K; Buttitta, F; Tornielli, S; Pellegrini, S; Veronese, M, L; Manenti, G; Incarbone, M; Chella, A; Angeletti, C, A; Pastorino, U; Huebner, K; Bevilaqua, G; Pilotti, S; Croce, C, M; Pierotti, M A. "Association between cigarette smoking and FHIT gene alterations in lung cancer." Cancer research. 57. 11 (1997) 2121-3. Ennas, M, G; Sorio, C; Greim, R; Nieddu, M; Scarpa, A; Orlandini, S; Croce, C, M; Fey, G, H; Marschalek, R. "The human ALL-1/MLL/HRX antigen is predominantly localized in the nucleus of resting and proliferating peripheral blood mononuclear cells." Cancer research. 57. 10 (1997) 2035-41. Condorelli, G, L; Tocci, A; Botta, R; Facchiano, F; Testa, U; Vitelli, L; Valtieri, M; Croce, C, M; Peschle, C. "Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade." Molecular and cellular biology. 17. 5 (1997) 2954-69. Zimonjic, D, B; Druck, T; Ohta, M; Kastury, K; Croce, C, M; Popescu, N, C; Huebner, K. "Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene." Cancer research. 57. 6 (1997) 1166-70. Cuneo, A; Bigoni, R; Negrini, M; Bullrich, F; Veronese, M, L; Roberti, M, G; Bardi, A; Rigolin, G, M; Cavazzini, P; Croce, C, M; Castoldi, G. "Cytogenetic and interphase cytogenetic characterization of atypical chronic lymphocytic leukemia carrying BCL1 translocation." Cancer research. 57. 6 (1997) 1144-50. Carson, W, E; Fehniger, T, A; Haldar, S; Eckhert, K; Lindemann, M, J; Lai, C, F; Croce, C, M; Baumann, H; Caligiuri, M A. "A potential role for interleukin-15 in the regulation of human natural killer cell survival." The Journal of clinical investigation. 99. 5 (1997) 937-43. Rogaia, D; Grignani, F; Carbone, R; Riganelli, D; LoCoco, F; Nakamura, T; Croce, C, M; Di Fiore, P, P; Pelicci, P G. "The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner." Cancer research. 57. 5 (1997) 799-802. Cimino, G; Lanza, C; Elia, L; Lo Coco, F; Gaidano, G; Biondi, A; Pastore, C; Serra, A; Canaani, E; Croce, C, M; Mandelli, F; Saglio, G. "Multigenetic lesions in infant acute leukaemias: correlations with ALL-1 gene status." British journal of haematology. 96. 2 (1997) 308-13. Jena, N; Martin-Seisdedos, C; McCue, P; Croce, C M. "BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye." Experimental cell research. 230. 1 (1997) 28-37. Druck, T; Hadaczek, P; Fu, T, B; Ohta, M; Siprashvili, Z; Baffa, R; Negrini, M; Kastury, K; Veronese, M, L; Rosen, D; Rothstein, J; McCue, P; Cotticelli, M, G; Inoue, H; Croce, C, M; Huebner, K. "Structure and expression of the human FHIT gene in normal and tumor cells." Cancer research. 57. 3 (1997) 504-12. Haldar, S; Basu, A; Croce, C M. "Bcl2 is the guardian of microtubule integrity." Cancer research. 57. 2 (1997) 229-33. Huebner, K; Druck, T; Siprashvili, Z; Croce, C, M; Kovatich, A; McCue, P A. " Arthur G. James Cancer Hospital and Richard J. Solove Research Institute 1082 Biomedical Research Tower 460 West 12th Avenue Columbus, OH 43210 Telephone: 614.292.3063