Flavia Pichiorri, PhD

Post Doctoral Researcher

Department of Molecular Virology, Immunology and Medical Genetics
Comprehensive Cancer Center

1060 Biomedical Research Tower
460 W 12th Avenue
Columbus, OH 43210

Flavia.Pichiorri@osumc.edu

Education:
University of Rome “Tor Vergata”     MS   1999   Molecular Biology

University of Rome “Tor Vergata”     PhD  2006   Experimental Medicine

Publications:

S. Pucci, E. Bonanno, F. Pichiorri, L.G. Spagnoli. Tumor Specific Modulation of Clusterin Isoforms in Human Colon Carcinoma. Oncogene. 2004 Mar 25;23(13):2298-304.

G. Contino, F. Amati, S. Pucci, E. Pontieri, , F. Pichiorri A. Novelli, A. Botta, R. Mango, A.M. Nardone, F.C. Sangiuolo, G. Citro, L.G. Spagnoli, G. Novelli. Characterization of The Human Gene Encoding for The U-box-type ubiquitin ligase UBE4A. Gene. 2004 Mar 17;328:69-74.

S. Pucci, E. Bonanno, F. Pichiorri, P. Mazzarelli, L.G. Spagnoli. Expression and Nuclear Activity of the Caretaker Gene Ku 86 are Modulated by Somatostatin. Eur J Histochem. 2004 Apr-Jun;48(2):103-10.

Orlandi A, Pucci S, Ciucci A, Pichiorri F, Ferlosio A, Spagnoli LG. Modulation of clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and apoptosis of intimal smooth muscle cells. Arterioscler Thromb Vasc Biol. 2005;25(2):348-53. Epub 2004 Dec 9.

G.A. Calin, M. Ferracin, A. Cimino, G. Di Leva, F. Pichiorri, et al, C.M. Croce. A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leucemia. New England journal of Medicine. 2005; 353(17):1793-801

F. Pichiorri, F. Trapasso, T. Palumbo, R. Aqeilan, A. Drusco, B. Blaser, M. Caligiuri, K. Huebner  and CM. Croce Preclinical assessment of FHIT replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35. Clinical Cancer Research. 2006 1;12(11 Pt 1):3494-501

R. Garzon, F. Pichiorri, T. Palombo, R. Iuliano, A. Cimmino, R. Aqeilan, S. Volinia, D. Bhatt, M. Andreeff and Carlo M. Croce. MicroRNA fingerprints during human megakaryocyto poiesis. PNAS, 2006; 103: 5078-5083

R. Garzon*, F. Pichiorri*, T. Palombo, A. Cimmino, R. Iuliano and CM Croce. Differential expression of MicroRNA in human granulocytic differentiation. Oncogene. 2007 Jun 14;26(28):4148-57.

(*equal contributors)

Rami I. Aqeilan, John P. Hagan, Haifa A. Aqeilan, Flavia Pichiorri, Louise Y.Y. Fong and Carlo M. Croce. Inactivation of the Wwox Gene Accelerates Forestomach Tumor Progression In vivo. Cancer Res. 2007 Jun 15;67(12):5606-10.

Lanza G, Ferracin M, Gafà R, Veronese A, Spizzo R, Pichiorri F, Liu CG, Calin GA, Croce CM, Negrini M.. mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. Mol Cancer. 2007; 6:54.

G. Calin, A. Cimmino, M. Fabbri, E. Tilli, F. Pichiorri, M. Shimizzu, S. Volinia, M. Negrini and C.M. Croce. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007 Sep; 12(3):215-29.

Trapassso F*, Pichiorri F*, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM. FHIT interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem, 2008; 283(20):13736-44.

(*equal contributors)

Pichiorri F, Ishii H, Okumura H, Trapasso F, Wang Y, Huebner K. Molecular parameters of genome instability: Roles of fragile genes at common fragile sites. J Cell Biochem. 2008;104(5):1525-33 featured on cover

Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Trapasso F, Vecchione A, Croce CM, Huebner K. Fhit affects survival of hematopoietic stem cells exposed to hydroquinine, a benzene metabolite. Cancer Research, 2008; 68(10):3662-70

Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP, Munker R, Volinia S, Boccadoro M, Garzon R, Palumbo A, Aqeilan RI, Croce CM. MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. PNAS, 2008; 105(35):12885-90.

Pichiorri F, Okumura H, Nakamura T, Garrison PN, Gasparini P, Suh S-S, Druck T, McCorkell KA,  Barnes LD, Croce CM, Huebner K. Correlation of Fhit structural features with effector interactions and biological functions. J Biol Chem, Nov. 2008

Pichiorri F, Palumbo T, Okumura H, Ishii H, Huebner K, Croce CM. The Fhit tumor suppressor: ‘guardian of the preneoplastic genome’. Future Oncology, in press, 2008